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Ap4dT

CAT: 0804-HY-168345ASize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-168345ASize:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Ap4dT is an inhibitor for human adenylate kinase isozyme 1 (hAK1), that inhibits the ATP and ADP synthesis with IC50s of 42 μM and 38 μM[1].
CAS Number
13457-68-6
UNSPSC
12352005
Target
DNA/RNA Synthesis
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Others
Smiles
O[C@@H]1[C@H](O)[C@@H](COP(OP(OP(OP(OC[C@@H](O2)[C@@H](O)C[C@@H]2N3C(NC(C(C)=C3)=O)=O)(O)=O)(O)=O)(O)=O)(O)=O)O[C@H]1N4C5=NC=NC(N)=C5N=C4
Molecular Formula
C20H29N7O20P4
Molecular Weight
811.37
References & Citations
[1]Kozakiewicz-Piekarz A, et al., Synthesis, kinetic studies, and QSAR of dinucleoside polyphosphate derivatives as human AK1 inhibitors. Bioorg Chem. 2024 Jul;148:107432.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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