Artefenomel (Standard)

CAT: 0804-HY-16762R-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-16762R-01Size:1 mg
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Description
Artefenomel (Standard) is the analytical standard of Artefenomel. This product is intended for research and analytical applications. Artefenomel (OZ439) is an orally active, synthetic anti-malarial compound containing an artemisinin pharmacophore with a mechanism of action similar to that of artemisinin. Artefenomel has antiviral activity against SARS-CoV-2[1][2].
CAS Number
[1029939-86-3]
UNSPSC
12352100
Target
Ferroptosis; Parasite; Reference Standards; SARS-CoV
Related Pathways
Anti-infection; Apoptosis; Others
Field of Research
Infection
Smiles
[H][C@@]1(C[C@H](C2)C3)C4([C@@]3([H])C[C@H]2C1)O[C@]5(OO4)CC[C@H](CC5)C6=CC=C(C=C6)OCCN7CCOCC7
Molecular Formula
C28H39NO5
Molecular Weight
469.61
References & Citations
[1] Joëlle Jourdan, et al. Monoclonal Antibodies That Recognize the Alkylation Signature of Antimalarial Ozonides OZ277 (Arterolane) and OZ439 (Artefenomel) . ACS Infect Dis. 2016 Jan 8;2 (1) :54-61.|[2]Tania Massignan, et al. Antimalarial Artefenomel Inhibits Human SARS-CoV-2 Replication in Cells while Suppressing the Receptor ACE2.|[3] Robert L Clark, et al. Improved safety margin for embryotoxicity in rats for the new endoperoxide artefenomel (OZ439) as compared to artesunate. Birth Defects Res. 2018 Apr 17;110 (7) :553-578.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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