Pam2Cys

CAT: 0804-HY-165613Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-165613Size:1 Each
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Description
Pam2Cys (Dipalmitoyl-S-glyceryl-cysteine; S-[2,3-Bis (palmitoyloxy) propyl]cysteine) is a selective agonist of dendritic cell TLR2, targeting the lipid portion of dendritic cells. Pam2Cys works by targeting and activating dendritic cells, thereby inducing strong immune responses, such as the production of specific antibodies. Pam2Cys enhances immunogenicity without the need for exogenous adjuvants. Pam2Cys can be applied to vaccine research, especially the development of lipopeptide vaccines against influenza A virus and other viruses to induce protective immune responses[1][2][3].
CAS Number
[656831-18-4]
Product Name Alternative
Dipalmitoyl-S-glyceryl-cysteine; S-[2,3-Bis (palmitoyloxy) propyl]cysteine
UNSPSC
12352211
Target
Toll-like Receptor (TLR)
Related Pathways
Immunology/Inflammation
Field of Research
Infection; Inflammation/Immunology
Smiles
O=C([C@@H](N)CSCC(OC(CCCCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCCCC)=O)O
Molecular Formula
C38H73NO6S
Molecular Weight
672.05
References & Citations
[1]Pejoski D, et al. A lipopeptide based on the M2 and HA proteins of influenza A viruses induces protective antibody. Immunol Cell Biol. 2010 Jul;88 (5) :605-11.|[2]Franzoni G, et al. Targeting Toll-Like Receptor 2: Polarization of Porcine Macrophages by a Mycoplasma-Derived Pam2cys Lipopeptide. Vaccines (Basel) . 2021 Jun 23;9 (7) :692.|[3]Tan AC, et al. Intranasal administration of the TLR2 agonist Pam2Cys provides rapid protection against influenza in mice. Mol Pharm. 2012 Sep 4;9 (9) :2710-8.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
TLR2

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