CR-3294

• Description :

  CR-3294 is an autophagy inducer in hypoxic cells. CR-3294 is an inducible enzyme nitric oxide synthase (iNOS) inhibitor. CR-3294 inhibits both the DNA binding of HIF-1alpha and VEGF mRNA synthesis. CR-3294 can be used for the study of breast cancer and inflammatory bowel disease (IBD), such as Crohn’s disease, ulcerative colitis[1].

• UNSPSC :

  12352005

• Target :

  Autophagy; NO Synthase

• Related Pathways :

  Autophagy; Immunology/Inflammation

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Cancer; Inflammation/Immunology

• Smiles :

  CC(NC1=CC=C(NC(NCCCCC)=S)C=C1)=N

• Molecular Formula :

  C14H22N4S

• Molecular Weight :

  278.42

• References & Citations :

  [1]Tafani M, et al. Induction of autophagic cell death by a novel molecule is increased by hypoxia. Autophagy. 2008 Nov;4 (8) :1042-53.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 2

• Isoform :

  INOS

• CAS Number :

  [457939-22-9]