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1954U89

CAT: 0804-HY-160254Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-160254Size:1 Each
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Description
1954U89 is a potent, lipid-soluble and orally active inhibitor of dihydrofolate reductase (DHFR) . 1954U89 exhibits anticancer activity[1][2].
CAS Number
150057-49-1
UNSPSC
12352005
Target
Dihydrofolate reductase (DHFR)
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
CC(N1C(CC)CC)=CC2=C1C=CC3=NC(N)=NC(N)=C23
Molecular Formula
C16H21N5
Molecular Weight
283.37
References & Citations
[1]Chen J C, et al. QSAR Studies on a Series of 7, 8‐Dialkyl‐1, 3‐diaminopyrrolo‐[3, 2‐f] quinazolines with Anticancer Activity[J]. Chinese Journal of Chemistry, 2006, 24 (11) : 1531-1537.|[2]Studenberg SD, et al. The pharmacokinetics of 1954U89, 1,3-diamino-7- (1-ethylpropyl) -8-methyl-7H-pyrrolo- (3,2-f) quinazoline, in dogs and rats after intravenous and oral administration. Biopharm Drug Dispos. 1997 Jul;18 (5) :433-42.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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