M17-B15

CAT: 0804-HY-159739Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-159739Size:1 Each
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
M17-B15 is an androgen receptor dimerization inhibitor with an IC50 of 30 nM. M17-B15 effectively disrupts AR self-association, thereby suppressing AR signaling. M17-B15 exhibits extraordinary anti- prostate cancer (PCa) efficacy in vitro and in mouse xenograft tumor models.M17-B15 can be used for the study of prostate cancer[1].
CAS Number
[708291-86-5]
UNSPSC
12352005
Target
Androgen Receptor
Related Pathways
Vitamin D Related/Nuclear Receptor
Field of Research
Cancer
Smiles
O=C(C1=C(C)OC(C2=CC(C(F)(F)F)=CC=C2)=C1)NC3=NC(CC(C)=O)=NS3
Molecular Formula
C18H14F3N3O3S
Molecular Weight
409.38
References & Citations
[1]Fu W, et al. Small-Molecule Inhibition of Androgen Receptor Dimerization as a Strategy against Prostate Cancer. ACS Cent Sci. 2023 Mar 8;9 (4) :675-684.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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