M17-B15

• Description:

  M17-B15 is an androgen receptor dimerization inhibitor with an IC50 of 30 nM. M17-B15 effectively disrupts AR self-association, thereby suppressing AR signaling. M17-B15 exhibits extraordinary anti- prostate cancer (PCa) efficacy in vitro and in mouse xenograft tumor models.M17-B15 can be used for the study of prostate cancer[1].

• UNSPSC:

  12352005

• Target:

  Androgen Receptor

• Related Pathways:

  Vitamin D Related/Nuclear Receptor

• Field of Research:

  Cancer

• Smiles:

  O=C (C1=C (C) OC (C2=CC (C (F) (F) F) =CC=C2) =C1) NC3=NC (CC (C) =O) =NS3

• Molecular Formula:

  C18H14F3N3O3S

• Molecular Weight:

  409.38

• References & Citations:

  [1]Fu W, et al. Small-Molecule Inhibition of Androgen Receptor Dimerization as a Strategy against Prostate Cancer. ACS Cent Sci. 2023 Mar 8;9 (4) :675-684.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  708291-86-5