DMOG (GMP)

• Description:

  DMOG (GMP) is the GMP level of DMOG (HY-15893) . GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. DMOG (GMP) is a HIF-1α stabilizer. DMOG (GMP) promotes the osteogenic, angiogenic, and chondrogenic differentiation of stem cells by stabilizing the expression of HIF-1α. DMOG (GMP) can enhance the osteogenic and angiogenic differentiation potential of stem cells, thereby improving bone regeneration in bone defects. DMOG (GMP) can be used in the research of bone defect repair, vascularized bone regeneration, and the treatment of bone-related diseases (such as osteoporosis and femoral head necrosis) [1].

• Product Name Alternative:

  Dimethyloxallyl Glycine (GMP)

• UNSPSC:

  12352211

• Hazard Statement:

  H302

• Target:

  Autophagy; HIF/HIF Prolyl-Hydroxylase

• Related Pathways:

  Autophagy; Metabolic Enzyme/Protease

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Cardiovascular Disease

• Smiles:

  O=C(OC)CNC(C(OC)=O)=O

• Molecular Formula:

  C6H9NO5

• Molecular Weight:

  175.14

• Precautions:

  P264-P270-P330-P501

• References & Citations:

  [1]Singh A, et al. Hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitors induce autophagy and have a protective effect in an in-vitro ischaemia model.Sci Rep. 2020 Jan 31;10 (1) :1597.|[2]Milkiewicz M, et al. Inhibition of endogenous HIF inactivation induces angiogenesis in ischaemic skeletal muscles of mice. J Physiol. 2004 Oct 1;560 (Pt 1) :21-6.|[3]Baader E, et al. Inhibition of prolyl 4-hydroxylase by oxalyl amino acid derivatives in vitro, in isolated microsomes and in embryonic chicken tissues. Biochem J. 1994 Jun 1;300 (Pt 2) :525-30.|[4]Li X, et al. Up-regulation of hypoxia-inducible factor-1α enhanced the cardioprotective effects of ischemic postconditioning in hyperlipidemic rats. Acta Biochim Biophys Sin (Shanghai) . 2014 Feb;46 (2) :112-8.|[5]Schultz K, et al. Prolyl hydroxylase 2 deficiency limits proliferation of vascular smooth muscle cells by hypoxia-inducible factor-1{alpha}-dependent mechanisms. Am J Physiol Lung Cell Mol Physiol. 2009 Jun;296 (6) :L921-7.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  GMP Small Molecules

• Clinical Information:

  No Development Reported

• CAS Number:

  [89464-63-1]