RegisterLogin

Estetrol

CAT: 0804-HY-15731-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-15731-01Size:5 mg
Selected
PRICE
AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
Estetrol, an orally active estrogen synthesized exclusively during pregnancy by the human fetal liver, is a selective nuclear estrogen receptor modulator. Estetrol binds ERα as well as ERβ (with a fourfold lower affinity) . Estetrol increases eNOS expression/activity and NO synthesis in endothelial cells. Estetrol exerts estrogenic actions on the endometrium or the central nervous system but presents antagonistic effects on the breast. Estetrol can be used in contraception and menopausal hormone research[1][2][3][4].
CAS Number
[15183-37-6]
UNSPSC
12352005
Hazard Statement
H351, H360, H362
Target
Endogenous Metabolite; Estrogen Receptor/ERR; NO Synthase
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease; Cancer
Purity
99.76
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
OC1=CC=C2C(CC[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])[C@@H](O)[C@@H](O)[C@@H]4O)=C1
Molecular Formula
C18H24O4
Molecular Weight
304.39
Precautions
H351, H360, H362
References & Citations
[1]Valéra MC, et al. Effect of estetrol, a selective nuclear estrogen receptor modulator, in mouse models of arterial and venous thrombosis. Mol Cell Endocrinol. 2018 Dec 5;477:132-139.|[2]Montt-Guevara MM, et al. Estetrol Modulates Endothelial Nitric Oxide Synthesis in Human Endothelial Cells. Front Endocrinol (Lausanne) . 2015 Jul 22;6:111.|[3]Abot A, et al. The uterine and vascular actions of estetrol delineate a distinctive profile of estrogen receptor α modulation, uncoupling nuclear and membrane activation. EMBO Mol Med. 2014 Oct;6 (10) :1328-46.|[4]Giretti MS, et al. Effects of Estetrol on Migration and Invasion in T47-D Breast Cancer Cells through the Actin Cytoskeleton. Front Endocrinol (Lausanne) . 2014 May 26;5:80.|[5]Coelingh Bennink HJ, et al. Ovulation inhibition by estetrol in an in vivo model. Contraception. 2008 Mar;77 (3) :186-90.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
Launched

Related Products

CatalogName

Alternative Products

CatalogName
RM-E192700-01Estetrol
BUP04375-01Estetrol
M33354-01Estetrol
sc-211425Estetrol
MBS5754843Estetrol
275022-01Estetrol
T15248-01Estetrol
MBS6068330-01Estetrol
MBS3845721-01Estetrol
A21291-5Estetrol 5mg

Popular Products