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GW9508 (Standard)

CAT: 0804-HY-15589R-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-15589R-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
GW9508 (Standard) is the analytical standard of GW9508. This product is intended for research and analytical applications. GW9508 is a potent and selective G protein-coupled receptors FFA1 (GPR40) and GPR120 agonist with pEC50s of 7.32 and 5.46, respectively. GW9508 shows ~100-fold selectivity for GPR40 over GPR120. GW9508 is inactive against other GPCRs, kinases, proteases, integrins and PPARs. GW9508 is a glucose-sensitive insulin secretagogue and an ATP-sensitive potassium (KATP) channels opener. Anti-inflammatory and anti-atherosclerotic activities[1][2][3][4].
CAS Number
885101-89-3
UNSPSC
12352100
Target
Free Fatty Acid Receptor; Potassium Channel; Reference Standards
Related Pathways
GPCR/G Protein; Membrane Transporter/Ion Channel; Others
Field of Research
Metabolic Disease; Inflammation/Immunology; Cardiovascular Disease
Smiles
O=C(O)CCC1=CC=C(NCC2=CC=CC(OC3=CC=CC=C3)=C2)C=C1
Molecular Formula
C22H21NO3
Molecular Weight
347.41
References & Citations
[1]Briscoe CP, et al. Pharmacological regulation of insulin secretion in MIN6 cells through the fatty acid receptor GPR40: identification of agonist and antagonist small molecules. Br J Pharmacol. 2006 Jul;148 (5) :619-28.|[2]Zhao YF, et al. Activation of ATP-sensitive potassium channels in rat pancreatic beta-cells by linoleic acid through both intracellular metabolites and membrane receptor signalling pathway. J Endocrinol, 2008, 198 (3), 533-540.|[3]Fujita T, et al. A GPR40 agonist GW9508 suppresses CCL5, CCL17, and CXCL10 induction in keratinocytes and attenuates cutaneous immune inflammation. J Invest Dermatol, 2011, 131 (8), 1660-1667.|[4]Suski M, et al. Anti-atherosclerotic action of GW9508 - Free fatty acid receptors activator - In apoE-knockout mice. Pharmacol Rep. 2019 Aug;71 (4) :551-555.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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Alternative Products

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A1709-5.1GW9508
A11965-10GW9508 10mg
A11965-200GW9508 200mg
A11965-25GW9508 25mg
A11965-100GW9508 100mg
A11965-5GW9508 5mg
A11965-50GW9508 50mg

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