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Piboserod (Standard)

CAT: 0804-HY-15574R-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-15574R-01Size:5 mg
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Description
Piboserod (Standard) is the analytical standard of Piboserod. This product is intended for research and analytical applications. Piboserod is an orally available selective antagonist of the 5-HT4 receptor, with a Ki value of approximately 0.1 nM for human 5-HT4 receptors. Piboserod can competitively bind to the 5-HT4 receptor and block the activation of the 5-HT4 receptor. Piboserod can inhibit the enhancing effect of 5-HT on the nerve-mediated contraction response of the human bladder detrusor muscle. Piboserod is mainly used in the research of urinary system diseases (such as overactive bladder) and cardiovascular diseases (such as chronic heart failure) [1][2][3][4].
CAS Number
152811-62-6
UNSPSC
12352100
Target
5-HT Receptor; Reference Standards
Related Pathways
GPCR/G Protein; Neuronal Signaling; Others
Field of Research
Cardiovascular Disease
Smiles
O=C(C1=C(OCCC2)N2C3=C1C=CC=C3)NCC4CCN(CCCC)CC4
Molecular Formula
C22H31N3O2
Molecular Weight
369.50
References & Citations
[1]Darblade B, et al. Piboserod (SB 207266), a selective 5-HT4 receptor antagonist, reduces serotonin potentiation of neurally-mediated contractile responses of human detrusor muscle. World J Urol. 2005 Jun;23 (2) :147-51.|[2]Kjekshus JK, et al. Effect of piboserod, a 5-HT4 serotonin receptor antagonist, on left ventricular function in patients with symptomatic heart failure. Eur J Heart Fail. 2009 Aug;11 (8) :771-8.|[3]Nirogi R, et al. In-vivo rat striatal 5-HT4 receptor occupancy using non-radiolabelled SB207145. J Pharm Pharmacol. 2013 May;65 (5) :704-12.|[4]McCullough JL, et al. The 5-HT2B antagonist and 5-HT4 agonist activities of tegaserod in the anaesthetized rat. Pharmacol Res. 2006 Apr;53 (4) :353-8.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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MBS3841159-01Piboserod
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A15542-500Piboserod 500mg
A15542-50Piboserod 50mg
A15542-100Piboserod 100mg
A15542-10Piboserod 10mg
A15542-2Piboserod 2mg
A15542-5Piboserod 5mg
A15542-1Piboserod 1mg

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