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Salubrinal (Standard)

CAT: 0804-HY-15486R-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-15486R-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Salubrinal (Standard) is the analytical standard of Salubrinal. This product is intended for research and analytical applications. Salubrinal is a cell-permeable and selective inhibitor of eIF2α dephosphorylation[1]. Salubrinal acts as a dual-specificity phosphatase 2 (Dusp2) inhibitor and suppresses inflammation in anti-collagen antibody-induced arthritis[2]. Salubrinal has antiviral activity against HSV-1 and inhibits dephosphorylation of eIF2α mediated by the HSV-1 protein ICP34.5[3].
CAS Number
405060-95-9
UNSPSC
12352100
Target
Apoptosis; Autophagy; HSV; Phosphatase; Reference Standards
Related Pathways
Anti-infection; Apoptosis; Autophagy; Metabolic Enzyme/Protease; Others
Field of Research
Cancer; Infection; Inflammation/Immunology
Smiles
O=C(NC(NC(NC1=CC=CC2=C1N=CC=C2)=S)C(Cl)(Cl)Cl)/C=C/C3=CC=CC=C3
Molecular Formula
C21H17Cl3N4OS
Molecular Weight
479.80
References & Citations
[1]Drexler HC. Synergistic Apoptosis Induction in Leukemic Cells by the Phosphatase Inhibitor Salubrinal and Proteasome Inhibitors. PLoS One. 2009;4 (1) :e4161.|[2]Hamamura K, et al. Salubrinal acts as a Dusp2 inhibitor and suppresses inflammation in anti-collagen antibody-induced arthritis. Cell Signal. 2015 Apr;27 (4) :828-35.|[3]Bryant KF, et al. ICP34.5-dependent and -independent activities of salubrinal in herpes simplex virus-1 infected cells. Virology. 2008 Sep 30;379 (2) :197-204.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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