Florbenazine

CAT: 0804-HY-153127Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-153127Size:1 Each

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Description

Florbenazine (AV-133) is a diagnostic imaging agent targeting the central nervous system monoamine transporter VMAT2, and its F-18 labeled form can be used for PET scanning. The biodistribution of [18F]Florbenazine in mice shows a high striatum/cerebellum ratio (0.48), which can be used for the diagnostic research of neurodegenerative diseases (including dementia with Lewy bodies and Parkinson's disease) [1].

CAS Number

937245-42-6

Product Name Alternative

AV-133

UNSPSC

12352005

Target

Biochemical Assay Reagents

Related Pathways

Others

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Smiles

COC1=C(OCCCF)C=C2CCN(C[C@H]([C@@H](C3)O)CC(C)C)[C@@]3([H])C2=C1

Molecular Formula

C21H32FNO3

Molecular Weight

365.48

References & Citations

[1]Zhu L, et al. An improved radiosynthesis of [18F]AV-133: a PET imaging agent for vesicular monoamine transporter 2. Nucl Med Biol. 2010 Feb;37 (2) :133-41.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

Phase 2

Florbenazine

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