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JZL195 (Standard)

CAT: 0804-HY-15250R-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-15250R-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
JZL195 (Standard) is the analytical standard of JZL195. This product is intended for research and analytical applications. JZL195 is a selective and efficacious dual fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) inhibitor with IC50s of 2 and 4 nM, respectively[1].
CAS Number
1210004-12-8
UNSPSC
12352100
Target
Autophagy; FAAH; MAGL; Reference Standards
Related Pathways
Autophagy; Metabolic Enzyme/Protease; Neuronal Signaling; Others
Field of Research
Neurological Disease
Smiles
O=C(OC1=CC=C([N+]([O-])=O)C=C1)N(CC2)CCN2CC3=CC(OC4=CC=CC=C4)=CC=C3
Molecular Formula
C24H23N3O5
Molecular Weight
433.46
References & Citations
[1]Long JZ, et al. Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivo. Proc Natl Acad Sci U S A. 2009 Dec 1;106 (48) :20270-5.|[2]Anderson WB, et al. Actions of the dual FAAH/MAGL inhibitor JZL195 in a murine inflammatory pain model. Neuropharmacology. 2014 Jun;81:224-30.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

Chemical Information

Jzl-195

inhibits both ​fatty-acid amide hydrolase 1 and ​monoglyceride lipase; structure in first source

CAS Number1210004-12-8
PubChem CID46232606
IUPAC Name(4-nitrophenyl) 4-[(3-phenoxyphenyl)methyl]piperazine-1-carboxylate
Molecular FormulaC24H23N3O5
Molecular Weight433.5
XLogP4.3
Topological Polar Surface Area87.8
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count6
Rotatable Bond Count6
Heavy Atom Count32
Formal Charge0
Complexity605
SMILES
C1CN(CCN1CC2=CC(=CC=C2)OC3=CC=CC=C3)C(=O)OC4=CC=C(C=C4)[N+](=O)[O-]
InChI
InChI=1S/C24H23N3O5/c28-24(32-22-11-9-20(10-12-22)27(29)30)26-15-13-25(14-16-26)18-19-5-4-8-23(17-19)31-21-6-2-1-3-7-21/h1-12,17H,13-16,18H2
InChIKey
QNYRAEKLMNDRFY-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Jzl-195
CAS: 1210004-12-8
CID: 46232606
Formula: C24H23N3O5
MW: 433.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight433.5
XLogP34.3
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count6
Rotatable Bond Count6
Exact Mass433.16377084
Monoisotopic Mass433.16377084
Topological Polar Surface Area87.8 Ų
Heavy Atom Count32
Formal Charge0
Complexity605
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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