Products for Research Use Only

MLN0905 (Standard)

CAT: 0804-HY-15155RSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-15155RSize:1 Each
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Description
MLN0905 (Standard) is the analytical standard of MLN0905. This product is intended for research and analytical applications. MLN0905 is a potent, orally active Polo-like kinase 1 (PLK1) inhibitor. MLN0905 has inhibitory potency against PLK1 with an IC50 value of 2 nM. MLN0905 can be used for the research of cancer[1][2].
CAS Number
1228960-69-7
UNSPSC
12352100
Target
Polo-like Kinase (PLK) ; Reference Standards
Related Pathways
Cell Cycle/DNA Damage; Others
Field of Research
Cancer
Smiles
CC1=NC=C(CCCN(C)C)C=C1NC2=NC(C(C=CC(C(F)(F)F)=C3)=C3NC(C4)=S)=C4C=N2
Molecular Formula
C24H25F3N6S
Molecular Weight
486.56
References & Citations
[1]Duffey MO, et al. Discovery of a potent and orally bioavailable benzolactam-derived inhibitor of Polo-like kinase 1 (MLN0905) . J Med Chem. 2012 Jan 12;55 (1) :197-208.|[2]Shi JQ, et al. MLN0905, a small-molecule plk1 inhibitor, induces antitumor responses in human models of diffuse large B-cell lymphoma. Mol Cancer Ther. 2012 Sep;11 (9) :2045-53.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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