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N6022 (Standard)

CAT: 0804-HY-14984R-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-14984R-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
N6022 (Standard) is the analytical standard of N6022. This product is intended for research and analytical applications. N6022 is a potent, selective, reversible, and efficacious S-Nitrosoglutathione reductase (GSNOR) inhibitor with IC50 of 8 nM.
CAS Number
1208315-24-5
UNSPSC
12352100
Target
GSNOR; Reference Standards
Related Pathways
Metabolic Enzyme/Protease; Others
Field of Research
Inflammation/Immunology
Smiles
OC(CCC1=CC=C(N1C2=CC=C(C(N)=O)C=C2C)C(C=C3)=CC=C3N4C=CN=C4)=O
Molecular Formula
C24H22N4O3
Molecular Weight
414.46
References & Citations
[1]Sun X, et al. Structure-activity relationships of pyrrole based S-nitrosoglutathione reductase inhibitors: pyrrole regioisomers and propionic acid replacement. Bioorg Med Chem Lett. 2011 Jun 15;21 (12) :3671-5.|[2]Colagiovanni DB, et al. A nonclinical safety and pharmacokinetic evaluation of N6022: a first-in-class S-nitrosoglutathione reductase inhibitor for the treatment of asthma. Regul Toxicol Pharmacol. 2012 Feb;62 (1) :115-24.|[3]Green LS, et al. Mechanism of inhibition for N6022, a first-in-class drug targeting S-nitrosoglutathione reductase. Biochemistry. 2012 Mar 13;51 (10) :2157-68.|[4]Thomas M. Raffay, et al. Methods of treating respiratory disorders. Patent. US 20170209419 A1.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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A13046-5N6022 5mg
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