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PY109

CAT: 0804-HY-147128Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-147128Size:1 Each
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Description
PY109 is an orally active and highly selective aryl hydrocarbon receptor (AHR) agonist. PY109's EC50 values in human-derived HepG2 and mouse Hepa-1c1c7 cells are 1.2 nM and 1.4 nM respectively. PY109 significantly upregulates the expression of CYP1A1 and IL-22, and inhibits the expression of IL-17A. PY109 significantly improves colitis in mice. PY109 can be used for research on colitis[1].
CAS Number
2378039-23-5
UNSPSC
12352005
Target
Aryl Hydrocarbon Receptor; Cytochrome P450; Interleukin Related
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease
Field of Research
Inflammation/Immunology
Smiles
O=C(C1=CNC2=C1C=CC=C2)C3=NC(C(F)(F)F)=CC=C3
Molecular Formula
C15H9F3N2O
Molecular Weight
290.24
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CYP1; IL-17; IL-22

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