L-733060

CAT: 0804-HY-14406Size: 1 EachDry Ice: NoHazardous: No

1 / 1

CAT#:0804-HY-14406Size:1 Each

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

Quick Request Actions

Description

L-733060 is a selective neurokinin-1 (NK-1) receptor antagonist. L-733060 mainly regulates pain transmission and neural plasticity by blocking the binding of Substance P (P substance) to the NK-1 receptor. L-733060 blocks the promoting effect of Substance P on long-term potentiation (LTP) in the hippocampus. L-733060 reverses the orofacial hyperalgesia induced by experimental occlusal interference (EOI) in rats. L-733060 hydrochloride inhibits neurogenic plasma extravasation at a dose that does not cause adverse cardiovascular effects in rodents, and also acts as an anti-tumor agent. L-733060 can be used for the study of chronic orofacial pain[1][2][3].

CAS Number

148700-85-0

UNSPSC

12352005

Target

Neurokinin Receptor

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Cancer-programmed cell death

Field of Research

Cancer; Neurological Disease

Smiles

FC(C1=CC(C(F)(F)F)=CC(CO[C@@H]2[C@H](C3=CC=CC=C3)NCCC2)=C1)(F)F

Molecular Formula

C20H19F6NO

Molecular Weight

403.36

References & Citations

[1]Langosch JM, et al. Effects of substance P and its antagonist L-733060 on long term potentiation in guinea pig hippocampal slices. Prog Neuropsychopharmacol Biol Psychiatry. 2005 Feb;29 (2) :315-9. |[2]SI-Yi Mo et al. Neuronal Activities in the Rostral Ventromedial Medulla Associated with Experimental Occlusal Interference-Induced Orofacial Hyperalgesia. J Neurosci. 2022 Jul 6;42 (27) :5314-5329. |[3]Muñoz M, et, al. Antitumoral action of the neurokinin-1 receptor antagonist L-733 060 on human melanoma cell lines. Melanoma Res. 2004 Jun;14 (3) :183-8.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

Phase 1

Isoform

NK1R

Related Products

Catalog	Name
HY-W928653	L-Seryl-L-leucyl-L-leucyl-L-lysine
HY-101552A-01	L, L-Dityrosine
HY-P4621-01	L-Alanyl-L-alanyl-L-glutamine
HY-W010789-01	L-Lysyl-L-tyrosine-α-L-lysine
HY-W101499-01	L-a-Aspartyl-L-leucine
HY-W101298-01	L-Leucyl-L-isoleucine
HY-W011607-01	L-Alanyl-L-tryptophan
HY-P4257	L-Isoleucyl-L-arginine
HY-129263-01	L-Isoleucyl-L-valine
HY-W967223-01	L-Phenylalanyl-L-threonine

Alternative Products

Catalog	Name
T22902-01	L-733060 hydrochloride
CCP1053-01	A-L-A-L
453309-01	L-Glycyl-L-lysyl-L-leucyl-L-isoleucyl-L-tyrosyl-L-seryl-L-alanyl-L-seryl-L-phenylalanyl-L-leucyl-L-tyrosyl-L-seryl-L-glycyl-L-valyl-L-prolyl-L-seryl-L-arganine
453434-01	L-Seryl-L-threonyl-L-glycyl-L-isoleucyl-L-seryl-L-valyl-L-prolyl-L-glycyl-L-prolyl-L-methionyl-L-glycyl-L-prolyl-L-seryl-L-glycyl-L-prolyl-L-Arginine
JH918176	L-Arginine, L-valyl-L-seryl-L-arginyl-L-arginyl-L-arginyl-L-arginyl-L-arginyl-L-arginylglycylglycyl-L-arginyl-L-arginyl-L-arginyl-
453216-01	L-Arginyl-L-valyl-L-α-aspartyl-L-prolyl-L-valyl-L-asparaginyl-L-phenylalanyl-L-lysyl-L-leucyl-L-leucyl-L-seryl-L-histidine
453308-01	L-Glycyl-L-arginyl-L-phenylalanyl-L-isoleucyl-L-threonyl-L-seryl-L-alanyl-L-aspartyl-L-threonyl-L-lysine
918629-48-8	L-Alanyl-L-Cysteinyl-L-Seryl-L-Seryl-L-Seryl-L-Prolyl-L-Seryl-L-Lysyl-L-Histidyl-L-Cysteinylglycine
453464-01	L-Tryptophyl-L-arginyl-L-glutaminyl-L-alanyl-L-alanyl-L-phenylalanyl-L-valyl-L-α-aspartyl-L-seryl-L-tyrosine
OR1066054-01	L-Tyrosyl-L-arginyl-L-seryl-L-arginyl-L-lysyl-L-tyrosyl-L-seryl-L-seryl-L-tryptophyl-L-tyrosine

L-733060

Related Products

Alternative Products

Popular Products