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Itanapraced (Standard)

CAT: 0804-HY-14399R-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-14399R-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Itanapraced (Standard) is the analytical standard of Itanapraced. This product is intended for research and analytical applications. Itanapraced (CHF5074) is an orally active γ-secretase modulator and a non-steroidal anti-inflammatory derivative. Itanapraced reduces Aβ42 and Aβ40 secretion with IC50 values of 3.6 and 18.4 μM, respectively. Itanapraced inhibits cell apoptosis of hippocampal neurons induced by oxygen and glucose deprivation (OGD) . Itanapraced can be used for the research of Alzheimer's disease[1][2].
CAS Number
749269-83-8
UNSPSC
12352100
Target
Apoptosis; Reference Standards; γ-secretase
Related Pathways
Apoptosis; Neuronal Signaling; Others; Stem Cell/Wnt
Field of Research
Neurological Disease
Smiles
OC(C1(CC1)C(C=C2)=CC(F)=C2C3=CC=C(Cl)C(Cl)=C3)=O
Molecular Formula
C16H11Cl2FO2
Molecular Weight
325.16
References & Citations
[1]Imbimbo BP, et al. 1- (3',4'-Dichloro-2-fluoro[1,1'-biphenyl]-4-yl) -cyclopropanecarboxylic acid (CHF5074), a novel gamma-secretasemodulator, reduces brain beta-amyloid pathology in a transgenic mouse model of Alzheimer's disease withoutcausing peripheral toxicity. J Pharmacol Exp Ther. 2007 Dec;323 (3) :822-830.|[2]Mango D, et al. Electrophysiological and metabolic effects of CHF5074 in the hippocampus: protection against in vitro ischemia. Pharmacol Res. 2014 Mar;81:83-90.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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