Vildagliptin-d6

• Description:

  Vildagliptin-d6 (LAF237-d6) is deuterium labeled Vildagliptin. Vildagliptin (LAF237) is a potent, stable, selective dipeptidyl peptidase IV (DPP-IV) inhibitor with an IC50 of 3.5 nM in human Caco-2 cells. Vildagliptin possesses excellent oral bioavailability and potent antihyperglycemic activity[1].

• Product Name Alternative:

  LAF237-d6 ; NVP-LAF 237-d6

• UNSPSC:

  12352005

• Target:

  Apoptosis; Dipeptidyl Peptidase; Ferroptosis; Isotope-Labeled Compounds

• Related Pathways:

  Apoptosis; Metabolic Enzyme/Protease; Others

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Metabolic Disease; Cancer

• Smiles:

  O=C(N1[C@@H](C([2H])([2H])C([2H])([2H])C1([2H])[2H])C#N)CNC23CC4(CC(CC(C4)C3)C2)O

• Molecular Formula:

  C17H19D6N3O2

• Molecular Weight:

  309.44

• References & Citations:

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Wu YJ, et al. Dipeptidyl peptidase-4 inhibitor, vildagliptin, inhibits pancreatic beta cell apoptosis in associationwith its effects suppressing endoplasmic reticulum stress in db/db mice. Metabolism. 2015 Feb;64 (2) :226-35.|[3]Villhauer EB, et al. 1-[[ (3-hydroxy-1-adamantyl) amino]acetyl]-2-cyano- (S) -pyrrolidine: a potent, selective, and orally bioavailable dipeptidyl peptidase IV inhibitor with antihyperglycemic properties. J Med Chem. 2003 Jun 19;46 (13) :2774-89.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Isotope-Labeled Compounds

• Clinical Information:

  No Development Reported