Methyltetrazine-acid

• Description:

  Methyltetrazine-acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Methyltetrazine-acid is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  PROTAC Linkers

• Related Pathways:

  PROTAC

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Purity:

  99.75

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=C(O)CC1=CC=C(C2=NN=C(C)N=N2)C=C1

• Molecular Formula:

  C11H10N4O2

• Molecular Weight:

  230.23

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  Alkyl-Chain Linkers

• CAS Number:

  [1380500-88-8]