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APN-PEG36-tetrazine

CAT: 0804-HY-139859-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-139859-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
APN-PEG36-tetrazine is an analogue of APN-PEG4-tetrazine. APN-PEG4-tetrazine is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1]. APN-PEG36-tetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
UNSPSC
12352203
Target
ADC Linker
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Cancer
Purity
96.05
Solubility
DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
N#CC#CC1=CC=C(C(NCCOCCOCCC(NCC2=CC=C(C3=NN=CN=N3)C=C2)=O)=O)C=C1.[35]
Molecular Formula
C94H161N7O38
Molecular Weight
1997.30
References & Citations
[1]Beck A, et, al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16 (5) :315-337.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Scientific Category
ADC Related
Clinical Information
No Development Reported

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