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GMQ

CAT: 0804-HY-139226Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-139226Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
GMQ is an acid-sensing ion channel modulator, competitive GABAAR antagonist. GMQ preferentially, potently, competitively inhibits GABAARs. GMQ inhibits α1β2, α1β2γ2, α4β2γ2 and α5β2γ2 GABAARs. GMQ enhances neuronal excitation through inhibition of GABAergic transmission. GMQ has anti-histamine effects in the enteric system, inhibiting gastric acid secretion[1].
CAS Number
716-11-0
Product Name Alternative
2-Guanidine-4-methylquinazoline
UNSPSC
12352005
Hazard Statement
H315-H319-H335
Target
GABA Receptor
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Smiles
NC(NC1=NC(C)=C2C=CC=CC2=N1)=N
Molecular Formula
C10H11N5
Molecular Weight
201.23
Precautions
P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501
References & Citations
[1]Xiao X, et al. 2-Guanidine-4-methylquinazoline acts as a novel competitive antagonist of A type γ-aminobutyric acid receptors. Neuropharmacology. 2013 Dec;75:126-37.
Shipping Conditions
Room temperature
Scientific Category
Reference compound2
Clinical Information
No Development Reported

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