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MEPB

CAT: 0804-HY-139046Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-139046Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MEPB is a modulator of AF-2 of the androgen receptor. MEPB increases co-repressor binding of AR. MEPB can bind to the BF3 pocket of AR specifically, thereby modulating the binding of co-regulators to the AF2 domain. MEPB alleviates degeneration in spinal bulbar muscular atrophy mouse model[1].
CAS Number
331948-99-3
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Adrenergic Receptor
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Smiles
CC1=CC=C(OCCN2C3=CC=CC=C3N=C2SCCOC4=CC=CC=C4)C=C1
Molecular Formula
C24H24N2O2S
Molecular Weight
404.52
Precautions
P261-P280-P302+P352
References & Citations
[1]Badders, N. M., et al., (2018) . Selective modulation of the androgen receptor AF2 domain rescues degeneration in spinal bulbar muscular atrophy. Nature medicine, 24 (4), 427-437.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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