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A-278637

CAT: 0804-HY-138983Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-138983Size:1 Each
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Description
A-278637 is a selective KATP channel opening agent with an EC50 of 102 nM. A-278637 does not interact with other ion channels, including L-type calcium channels or other neurotransmitter receptor systems. A-278637 possesses a greater functional selectivity for urinary bladder versus vascular smooth muscle in vivo. A-278637 can be used for the study of overactive bladder[1][2].
CAS Number
227609-66-7
UNSPSC
12352005
Target
Potassium Channel
Related Pathways
Membrane Transporter/Ion Channel
Field of Research
Neurological Disease
Smiles
O=S1(C2=C(CC1)NC(CCCC3=O)=C3[C@]2([H])C4=CC(Br)=C(C=C4)F)=O
Molecular Formula
C17H15BrFNO3S
Molecular Weight
412.27
References & Citations
[1]Fryer RM, et al. (-) - (9S) -9- (3-Bromo-4-fluorophenyl) -2,3,5,6,7,9-hexahydrothieno[3,2-b]quinolin-8 (4H) -one 1,1-dioxide (A-278637), a novel ATP-sensitive potassium channel opener: hemodynamic comparison to ZD-6169, WAY-133537, and nifedipine in the anesthetized canine. J Cardiovasc Pharmacol. 2004 Aug;44 (2) :137-47. |[2]Gopalakrishnan M, et al. (-) - (9S) -9- (3-Bromo-4-fluorophenyl) -2,3,5,6,7,9-hexahydrothieno[3,2-b]quinolin-8 (4H) -one 1,1-dioxide (A-278637) : a novel ATP-sensitive potassium channel opener efficacious in suppressing urinary bladder contractions. I. In vitro characterization. J Pharmacol Exp Ther. 2002 Oct;303 (1) :379-86.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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CatalogName
CJA60966-01A-278637

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