HT1171

• Description :

  HT1171 is a potent and selective inhibitor of mycobacterium tuberculosis proteasome. HT1171 shows strong anti-tuberculosis activity against Mycobacterium tuberculosis H37Rv with an MIC90 of 2 μg/mL and an MIC of 4 μg/mL. When HT1171 concentration is 100 μM, the inhibition rate of human normal hepatocytes L02 is 53.8%. HT1171 can be used in the research of antitubercular agent[1][2].

• UNSPSC :

  12352005

• Hazard Statement :

  H302

• Target :

  Bacterial; Virus Protease

• Related Pathways :

  Anti-infection

• Field of Research :

  Infection

• Smiles :

  O=C1OC(C2=CC([N+]([O-])=O)=C(C)S2)=NS1

• Molecular Formula :

  C7H4N2O4S2

• Molecular Weight :

  244.25

• Precautions :

  P264-P270-P330-P501

• References & Citations :

  [1]Almeleebia TM, et al. Identification of New Mycobacterium tuberculosis Proteasome Inhibitors Using a Knowledge-Based Computational Screening Approach. Molecules. 2021 Apr 16;26 (8) :2326.|[2]Yang J, et al. 3H-1,2,4-Dithiazol-3-one compounds as novel potential affordable antitubercular agents. Bioorg Med Chem Lett. 2013 Mar 1;23 (5) :1424-7.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [192880-96-9]