HT1171

CAT: 0804-HY-138958-01Size: 25 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-138958-01Size:25 mg

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Description

HT1171 is a potent and selective inhibitor of mycobacterium tuberculosis proteasome. HT1171 shows strong anti-tuberculosis activity against Mycobacterium tuberculosis H37Rv with an MIC90 of 2 μg/mL and an MIC of 4 μg/mL. When HT1171 concentration is 100 μM, the inhibition rate of human normal hepatocytes L02 is 53.8%. HT1171 can be used in the research of antitubercular agent[1][2].

CAS Number

192880-96-9

UNSPSC

12352005

Hazard Statement

H302

Target

Bacterial; Virus Protease

Related Pathways

Anti-infection

Field of Research

Infection

Smiles

O=C1OC(C2=CC([N+]([O-])=O)=C(C)S2)=NS1

Molecular Formula

C7H4N2O4S2

Molecular Weight

244.25

Precautions

P264-P270-P330-P501

References & Citations

[1]Almeleebia TM, et al. Identification of New Mycobacterium tuberculosis Proteasome Inhibitors Using a Knowledge-Based Computational Screening Approach. Molecules. 2021 Apr 16;26 (8) :2326.|[2]Yang J, et al. 3H-1,2,4-Dithiazol-3-one compounds as novel potential affordable antitubercular agents. Bioorg Med Chem Lett. 2013 Mar 1;23 (5) :1424-7.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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