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Vepdegestrant-d5

CAT: 0804-HY-138642SSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-138642SSize:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Vepdegestrant-d5 (ARV-471-d5) is the deuterium labeled Vepdegestrant. Vepdegestrant (ARV-471) is an orally active PROTAC estrogen receptor degrader against breast cancer. Vepdegestrant is a hetero-bifunctional molecule that facilitates the interactions between estrogen receptor alpha and an intracellular E3 ligase complex. Vepdegestrant leads to the ubiquitylation and subsequent degradation of estrogen receptors via the proteasome. Vepdegestrant robustly degrades ER in ER-positive breast cancer cell lines with a DC50 of about 2 nM[1].
CAS Number
3025452-07-4
Product Name Alternative
ARV-471-d5
UNSPSC
12352005
Target
Isotope-Labeled Compounds
Related Pathways
Others
Field of Research
Cancer
Smiles
O=C1NC([C@@H](N(C2=O)CC3=C2C=CC(N(CC4)CCN4CC(CC5)CCN5C(C=C6)=CC=C6[C@H]7[C@@H](C8=C([2H])C([2H])=C([2H])C([2H])=C8[2H])CCC9=C7C=CC(O)=C9)=C3)CC1)=O
Molecular Formula
C45H44D5N5O4
Molecular Weight
728.93
References & Citations
[1]Lin X, et al. Targeting estrogen receptor α for degradation with PROTACs: A promising approach to overcome endocrine resistance. Eur J Med Chem. 2020;206:112689.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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