(±) -Spiro-oxanthromicin A

CAT: 0804-HY-137971Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-137971Size:1 Each
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Description
(±) -Spiro-oxanthromicin A (Compound 4), a polyketide, is a K-Ras inhibitor with an IC50 of 26.7 μM. (±) -Spiro-oxanthromicin A can be isolated from soil-derived Streptomyces sp. (±) -Spiro-oxanthromicin A can mislocalize oncogenic mutant K-Ras from the plasma membrane of intact MDCK cells. (±) -Spiro-oxanthromicin A can be used for cancers research[1].
CAS Number
[1616622-10-6]
UNSPSC
12352005
Target
Ras
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway
Field of Research
Cancer
Smiles
CC(C=C1C(C(C2=C3O)=CC=C3C)(CC=C(C(C4=C5C)=CC(O)=C5C(O)=O)C1=C6C4=O)C(C(C2=O)=C7C)=CC(O)=C7C(O)=O)=C6O
Molecular Formula
C36H26O10
Molecular Weight
618.59
References & Citations
[1]Salim AA, et al. Rare Streptomyces sp. polyketides as modulators of K-Ras localisation. Org Biomol Chem. 2014 Jul 21;12 (27) :4872-8.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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