DdCTP

• Description :

  DdCTP is one of 2',3'-dideoxyribonucleoside 5'-triphosphates (ddNTPs) that acts as chain-elongating inhibitor of DNA polymerase for DNA sequencing. ddCTP is a nucleoside analog that targets the reverse transcriptase of HIV. ddCTP can be used for AIDS research[1][2].

• CAS Number :

  [66004-77-1]

• UNSPSC :

  12352200

• Hazard Statement :

  H315-H319-H335

• Target :

  DNA/RNA Synthesis; HIV Protease

• Related Pathways :

  Anti-infection; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Infection

• Solubility :

  10 mM in DMSO

• Smiles :

  O=[P](O[P](O[P](O)(O)=O)(O)=O)(O)OC[C@@H]1CC[C@H](N2C(N=C(N)C=C2)=O)O1

• Molecular Formula :

  C9H16N3O12P3

• Molecular Weight :

  451.16

• Precautions :

  P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P362-P403+P233-P405-P501

• References & Citations :

  [1]Z G Chidgeavadze, et al. 3'-Fluoro-2',3'-dideoxyribonucleoside 5'-triphosphates: terminators of DNA synthesis. FEBS Lett. 1985 Apr 22;183 (2) :275-8.|[2]Pelletier H, et al. Structures of ternary complexes of rat DNA polymerase beta, a DNA template-primer, and ddCTP. Science. 1994 Jun 24;264 (5167) :1891-903.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Biochemical Assay Reagents

• Clinical Information :

  No Development Reported