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N19-0881

CAT: 0804-HY-136682Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-136682Size:1 Each
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Description
N19-0881 (Compound 33) is an orally active, potent and selective KDM5A/5B histone lysine demethylase inhibitor (IC50= 0.013 μM and 0.002 μM, respectively) . N19-0881 is promising for research of epigenetically dysregulated tumors (e.g., breast cancer) [1].
CAS Number
1613410-75-5
UNSPSC
12352005
Target
Histone Demethylase
Related Pathways
Epigenetics
Field of Research
Cancer
Smiles
O=C(C1=CC(N2N=CC=C2OCC3=CC=C(Cl)C=C3C)=NC=C1)O
Molecular Formula
C17H14ClN3O3
Molecular Weight
343.76
References & Citations
[1]Nie Z, et al. Structure-based design and discovery of potent and selective KDM5 inhibitors. Bioorg Med Chem Lett. 2018 May 15;28 (9) :1490-1494.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
KDM5

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