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MJ33

CAT: 0804-HY-136271Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-136271Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MJ-33 is a competitive phospholipase A₂ (PLA₂) inhibitor. MJ-33 inhibits the activation of NOX2 by blocking the PLA₂ activity of Prdx6, thereby reducing the production of ROS. MJ-33 effectively inhibits the activity of acidic PLA₂ (pH 4.0), reduces the degradation of pulmonary surfactant phosphatidylcholine (PC), but has no effect on alkaline PLA₂ (pH 8.5) . MJ-33 significantly alleviates lung oxidative damage induced by ischemia-reperfusion (I/R) . MJ-33 significantly inhibits the invasive, migratory and adhesive abilities of prostate cancer cells by suppressing the MAPK, AKT, NF-κB and AP-1 signaling pathways. MJ-33 can be used to study ROS-related diseases and prostate cancer[1][2][3].
CAS Number
137300-78-8
UNSPSC
12352211
Target
Akt; AP-1; NADPH Oxidase; NF-κB; p38 MAPK; Phospholipase; Reactive Oxygen Species (ROS)
Related Pathways
Immunology/Inflammation; MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB; PI3K/Akt/mTOR
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology; Cardiovascular Disease
Smiles
O=P(OC)(O)OC(COCCCCCCCCCCCCCCCC)COCC(F)(F)F
Molecular Formula
C22H44F3O6P
Molecular Weight
492.55
References & Citations
[1]Hour MJ, et al. Antitumor effects of the novel quinazolinone MJ-33: Inhibition of metastasis through the MAPK, AKT, NF-κB and AP-1 signaling pathways in DU145 human prostate cancer cells. International journal of oncology. 2012 Oct 1;41 (4) :1513-9.|[2]Lee I, et al. A novel nontoxic inhibitor of the activation of NADPH oxidase reduces reactive oxygen species production in mouse lung. The Journal of pharmacology and experimental therapeutics. 2013 May 1;345 (2) :284-96.|[3]Fisher AB, et al. A competitive inhibitor of phospholipase A2 decreases surfactant phosphatidylcholine degradation by the rat lung. Biochemical Journal. 1992 Dec 1;288 (2) :407-11.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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