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Sibenadet

CAT: 0804-HY-135487Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-135487Size:1 Each
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Description
Sibenadet (AR-C68397AA free base) is a dual dopamine D2/β2-adrenoceptor agonist with selective β2-adrenoceptor agonism. Sibenadet inhibits capsaicin-induced plasma protein extravasation in rat trachea. Sibenadet suppresses edema from sensory nerve fiber activation by activating β2-adrenoceptor. Sibenadet is promising for research of chronic obstructive pulmonary disease (COPD) [1].
CAS Number
154189-40-9
Product Name Alternative
AR-C68397AA (free base) ; AR-C68397XX
UNSPSC
12352005
Target
Adrenergic Receptor; Dopamine Receptor
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Smiles
O=C1SC2=C(CCNCCS(=O)(CCCOCCC3=CC=CC=C3)=O)C=CC(O)=C2N1
Molecular Formula
C22H28N2O5S2
Molecular Weight
464.60
References & Citations
[1]Fozard JR, et al. Inhibition by viozan of extravasation induced in rat trachea by capsaicin is mediated exclusively by beta 2-adrenoceptors. Naunyn Schmiedebergs Arch Pharmacol. 2001 Dec;364 (6) :570-2.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 3
Isoform
D2 Receptor; β adrenergic receptor

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T207535-01Sibenadet
MBS5778447Sibenadet hydrochloride

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