L-649923

CAT: 0804-HY-135288Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-135288Size:1 Each
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AVAILABILITY: InStock
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Description
L-649923 is an orally active CysLT1 antagonist. L-649923 reduced the incidence of gastritis in an animal model of acute gastric mucosal injury. L-649923 can be used in research on diseases such as asthma and gastritis[1][2].
CAS Number
[114370-57-9]
UNSPSC
12352005
Target
Leukotriene Receptor
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Smiles
OC(C[C@H](C)[C@@H](O)C(C=C1)=CC=C1SCCCOC2=C(C(O)=C(C(C)=O)C=C2)CCC)=O
Molecular Formula
C25H32O6S
Molecular Weight
460.58
References & Citations
[1]Gyömber E, et al. Effect of lipoxygenase inhibitors and leukotriene antagonists on acute and chronic gastric haemorrhagic mucosal lesions in ulcer models in the rat. J Gastroenterol Hepatol. 1996 Oct;11 (10) :922-7.|[2]Jacques CA, et al. The contractile activities of lipoxin A4 and lipoxin B4 for guinea-pig airway tissues. Br J Pharmacol. 1988 Oct;95 (2) :562-8.|[3]McMahon TJ, et al. Influence of SQ 30741 on thromboxane receptor-mediated responses in the feline pulmonary vascular bed. J Appl Physiol (1985) . 1991 Nov;71 (5) :2012-8.|[4]Küng CF, et al. Different mechanisms of endothelial dysfunction with aging and hypertension in rat aorta. Hypertension. 1995 Feb;25 (2) :194-200.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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