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ATP-γ-S (tetrasodium)

CAT: 0804-HY-134361Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-134361Size:1 Each
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Description
ATP-γ-S (tetrasodium) is a P2Y11 receptor agonist, an antioxidant and a neuroprotective agent. ATP-γ-S (tetrasodium) can be used as a substrate for the nucleotide hydrolysis and RNA unwinding activities of eukaryotic translation initiation factor eIF4A. ATP-γ-S (tetrasodium) is active in ATP hydrolysis[1][2][3][4][5].
CAS Number
88453-52-5
UNSPSC
12352005
Target
Eukaryotic Initiation Factor (eIF) ; P2Y Receptor
Related Pathways
Cell Cycle/DNA Damage; GPCR/G Protein
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease; Inflammation/Immunology; Neurological Disease
Solubility
10 mM in DMSO
Smiles
O[C@@H]([C@H]([C@@](N1C=NC2=C1N=CN=C2N)([H])O3)O)[C@H]3COP(OP(OP(O[Na])(S[Na])=O)(O[Na])=O)(O[Na])=O
Molecular Formula
C10H12N5Na4O12P3S
Molecular Weight
611.17
References & Citations
[1]Ortal Danino, et al. ATP-γ-S- (α, β-CH2) protects against oxidative stress and amyloid beta toxicity in neuronal culture. Biochem Biophys Res Commun. 2015 May 1;460 (2) :446-50. |[2]J W Lee, et al. Inhibition of recA protein promoted ATP hydrolysis. 1. ATP gamma S and ADP are antagonistic inhibitors. Biochemistry. 1990 Aug 21;29 (33) :7666-76.|[3]Matthew L Peck, et al. Adenosine 5'-O- (3-thio) triphosphate (ATPgammaS) is a substrate for the nucleotide hydrolysis and RNA unwinding activities of eukaryotic translation initiation factor eIF4A. RNA. 2003 Oct;9 (10) :1180-7.|[4]Z Y Wang, et al. Mg2+ and ATP or adenosine 5'-[gamma-thio]-triphosphate (ATP gamma S) enhances intrinsic fluorescence and induces aggregation which increases the activity of spinach Rubisco activase. Biochim Biophys Acta. 1993 Sep 3;1202 (1) :47-55.|[5]Irina A Kolosova, et al. Protective effect of purinergic agonist ATPgammaS against acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2008 Feb;294 (2) :L319-24.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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