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Varespladib-d7

CAT: 0804-HY-13402S-01Size: 500 µgDry Ice: NoHazardous: No
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CAT#:0804-HY-13402S-01Size:500 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Varespladib-d7 (LY315920-d7) is a deuterated labeled Varespladib. Varespladib is a potent and selective group IIA, secretory phospholipase A2 (sPLA2) inhibitor with an IC50 of 9 nM. Varespladib exhibits the significant inhibitory effect on sPLA2 activity in serum from various species including rat, rabbit, guinea pig and human with IC50s of 8.1 nM, 5.0 nM, 3.2 nM and 6.2 nM, respectively[1].
CAS Number
1360701-64-9
Product Name Alternative
LY315920-d7
UNSPSC
12352005
Target
Isotope-Labeled Compounds; Phospholipase
Related Pathways
Metabolic Enzyme/Protease; Others
Field of Research
Inflammation/Immunology
Smiles
O=C(O)COC1=CC=CC2=C1C(C(C(N)=O)=O)=C(CC)N2C([2H])([2H])C3=C([2H])C([2H])=C([2H])C([2H])=C3[2H]
Molecular Formula
C21H13D7N2O5
Molecular Weight
387.44
References & Citations
[1]Snyder DW, et al. Pharmacology of LY315920/S-5920, [[3- (aminooxoacetyl) -2-ethyl-1- (phenylmethyl) -1H-indol-4-yl]oxy] acetate, a potent and selective secretory phospholipase A2 inhibitor: A new class of anti-inflammatory drugs, SPI. J Pharmacol Exp Ther. 1999 Mar;288 (3) :1117-24.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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