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Glucopiericidin A

CAT: 0804-HY-133541Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-133541Size:1 Each
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Description
Glucopiericidin A is a natural piericidin compound obtained from a marine-derived Streptomyces strain. Glucopiericidin A serves as a glucose transporter (GLUT) chemical probe and suppresses glycolysis. Glucopiericidin A inhibits ATP-dependent filopodia protrusion with Piericidin A (PA; HY-114936) and has no effect alone. Glucopiericidin A induces cell apoptosis through reducing the reactive oxygen species (ROS) level by increasing PRDX1 and exhibits potent antitumor efficacy in ACHN mice xenografts[1][2].
CAS Number
108073-65-0
UNSPSC
12352005
Target
ADC Payload; Apoptosis; GLUT
Related Pathways
Antibody-drug Conjugate/ADC Related; Apoptosis; Membrane Transporter/Ion Channel
Applications
Cancer-programmed cell death
Field of Research
Cancer
Solubility
10 mM in DMSO
Smiles
COC1=NC(C/C=C(C)/C/C=C/C(C)=C/[C@@H](C)[C@H](/C(C)=C/C)O[C@@H]2O[C@@H]([C@H]([C@@H]([C@H]2O)O)O)CO)=C(C)C(O)=C1OC
Molecular Formula
C31H47NO9
Molecular Weight
577.71
References & Citations
[1]Mitsuhiro Kitagawa, et al. Metabolomic identification of the target of the filopodia protrusion inhibitor glucopiericidin A. Chem Biol. 2010 Sep 24;17 (9) :989-98.|[2]Xuefeng Zhou, et al. Exploring the Natural Piericidins as Anti-Renal Cell Carcinoma Agents Targeting Peroxiredoxin 1. J Med Chem. 2019 Aug 8;62 (15) :7058-7069.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported

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