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Pracinostat (Standard)

CAT: 0804-HY-13322R-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-13322R-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Pracinostat (Standard) is the analytical standard of Pracinostat. This product is intended for research and analytical applications. Pracinostat is a potent histone deacetylase (HDAC) inhibitor, with IC50s of 40-140 nM, used for cancer research. Pracinostat also inhibits metallo-β-lactamase domain-containing protein 2 (MBLAC2) hydrolase activity with an EC50 below 10 nM[1][4].
CAS Number
929016-96-6
UNSPSC
12352100
Target
Apoptosis; Beta-lactamase; HDAC; Reference Standards
Related Pathways
Anti-infection; Apoptosis; Cell Cycle/DNA Damage; Epigenetics; Others
Field of Research
Cancer
Smiles
ONC(/C=C/C1=CC=C2N(C(CCCC)=NC2=C1)CCN(CC)CC)=O
Molecular Formula
C20H30N4O2
Molecular Weight
358.48
References & Citations
[1]Novotny-Diermayr V, et al. SB939, a novel potent and orally active histone deacetylase inhibitor with high tumor exposure and efficacy in mouse models of colorectal cancer. Mol Cancer Ther. 2010 Mar;9 (3) :642-52.|[2]Wang H, et al. Discovery of (2E) -3-{2-butyl-1-[2- (diethylamino) ethyl]-1H-benzimidazol-5-yl}-N-hydroxyacrylamide (SB939), an orally active histone deacetylase inhibitor with a superior preclinical profile. J Med Chem. 2011 Jul 14;54 (13) :4694-720.|[3]Novotny-Diermayr V, et al. The oral HDAC inhibitor pracinostat (SB939) is efficacious and synergistic with the JAK2 inhibitor pacritinib (SB1518) in preclinical models of AML. Blood Cancer J. 2012 May;2 (5) :e69.|[4]Lechner S, et al. Target deconvolution of HDAC pharmacopoeia reveals MBLAC2 as common off-target. Nat Chem Biol. 2022 Aug;18 (8) :812-820.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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