ASN-1377642

• Description :

  ASN-1377642 is a NK1 receptor antagonist with a Ki value of 251 nM. ASN-1377642 shows antitumor action in breast cancer cells with NK1R-Tr high expression[1][2].

• UNSPSC :

  12352005

• Target :

  Neurokinin Receptor

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Field of Research :

  Cancer

• Purity :

  90.000000

• Smiles :

  O=C(NC1=CC=CC(Cl)=C1)CSC2=NN=C(C3=CC=NC=C3)N2C4=CC=CC=C4

• Molecular Formula :

  C21H16ClN5OS

• Molecular Weight :

  421.90

• References & Citations :

  [1]Zhou Y, et al. Roles of full-length and truncated neurokinin-1 receptors on tumor progression and distant metastasis in human breast cancer. Breast Cancer Res Treat. 2013 Jul;140 (1) :49-61.|[2]Evers A, et al. Ligand-supported homology modeling of g-protein-coupled receptor sites: models sufficient for successful virtual screening. Angew Chem Int Ed Engl. 2004 Jan;43 (2) :248-51.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C, 3 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  NK1R

• CAS Number :

  [337505-63-2]