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Tetrahydrocortisol

CAT: 0804-HY-129630-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-129630-01Size:5 mg
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Description
Tetrahydrocortisol is cortisol metabolite. The urinary Tetrahydrocortisol/Tetrahydrocortisone ratio decreases with increasing 11β-hydroxysteroid dehydrogenase (11β-HSD) activity[1][2].
CAS Number
53-02-1
UNSPSC
12352211
Hazard Statement
H225, H301+H311+H331, H370
Target
Endogenous Metabolite
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Concentration
10mM
Purity
99.91
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
C[C@@]12[C@](C(CO)=O)(O)CC[C@@]1([H])[C@]3([H])CC[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])[C@@H](O)C2
Molecular Formula
C21H34O5
Molecular Weight
366.49
Precautions
H225, H301+H311+H331, H370
References & Citations
[1]Webster SP, et al. Selection and early clinical evaluation of the brain-penetrant 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor UE2343 (Xanamem™) . Br J Pharmacol. 2017 Mar;174 (5) :396-408.|[2]Turpeinen U, et al. Determination of free tetrahydrocortisol and tetrahydrocortisone ratio in urine by liquid chromatography-tandem mass spectrometry. Scand J Clin Lab Invest. 2006;66 (2) :147-59.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Human Endogenous Metabolite

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