LY 178210

• Description :

  LY 178210 (Compound 24) is a selective partial agonist of the 5-HT1A receptor, with Ki values ​​of 0.67 and 380 nM for the 5-HT1A and 5-HT1D receptors, respectively. LY 178210 has almost no activity against α₂-adrenergic receptors, 5-HT₂, and other neurotransmitter receptors. LY 178210 inhibits Foscolin-stimulated cyclase activity, but its maximum potency is lower than that of the full agonist 8-OH-DPAT (HY-112061) . LY 178210 significantly reduces 5-hydroxyindoleacetic acid (5-HIAA) levels in the greater hypothalamus and increases serum corticosterone concentrations[1][2].

• CAS Number :

  [114943-19-0]

• UNSPSC :

  12352005

• Target :

  5-HT Receptor

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Smiles :

  O=C(C1=C2C3=C(NC=C3CC(N(CCC)CCC)C2)C=C1)N

• Molecular Formula :

  C18H25N3O

• Molecular Weight :

  299.41

• References & Citations :

  [1]Flaugh ME, et al. 6-substituted 1,3,4,5-tetrahydrobenz[cd]indol-4-amines: potent serotonin agonists. J Med Chem. 1988 Sep;31 (9) :1746-53.|[2]Slaughter JL, et al. 6-substituted tricyclic partial ergoline compounds are selective and potent 5-hydroxytryptamine1A receptor agents. Life Sci. 1990;47 (15) :1331-7.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  5-HT1 Receptor