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LY 178210

CAT: 0804-HY-129481Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-129481Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
LY 178210 (Compound 24) is a selective partial agonist of the 5-HT1A receptor, with Ki values ​​of 0.67 and 380 nM for the 5-HT1A and 5-HT1D receptors, respectively. LY 178210 has almost no activity against α₂-adrenergic receptors, 5-HT₂, and other neurotransmitter receptors. LY 178210 inhibits Foscolin-stimulated cyclase activity, but its maximum potency is lower than that of the full agonist 8-OH-DPAT. LY 178210 significantly reduces 5-hydroxyindoleacetic acid (5-HIAA) levels in the greater hypothalamus and increases serum corticosterone concentrations[1][2].
CAS Number
114943-19-0
UNSPSC
12352005
Target
5-HT Receptor
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Smiles
O=C(C1=C2C3=C(NC=C3CC(N(CCC)CCC)C2)C=C1)N
Molecular Formula
C18H25N3O
Molecular Weight
299.41
References & Citations
[1]Flaugh ME, et al. 6-substituted 1,3,4,5-tetrahydrobenz[cd]indol-4-amines: potent serotonin agonists. J Med Chem. 1988 Sep;31 (9) :1746-53.|[2]Slaughter JL, et al. 6-substituted tricyclic partial ergoline compounds are selective and potent 5-hydroxytryptamine1A receptor agents. Life Sci. 1990;47 (15) :1331-7.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
5-HT1 Receptor

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