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AZ1136

CAT: 0804-HY-128391Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-128391Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AZ1136 is a highly selective γ-secretase modulator (GSM) . AZ1136 reduces the levels of Aβ42 and Aβ40, with its IC50 being 990 and 1400 nM. AZ1136 increases the levels of Aβ39 and Aβ37, but does not affect Aβ38. AZ1136 can be used for the study of Alzheimer's disease[1].
CAS Number
1380508-60-0
UNSPSC
12352005
Target
Amyloid-β; γ-secretase
Related Pathways
Neuronal Signaling; Stem Cell/Wnt
Field of Research
Neurological Disease
Smiles
O=C1C2=CN=C(OC3=CC=C(C4=CN=CO4)C=C3)N=C2N(C)CC(C5=CC=CC=C5)N1C
Molecular Formula
C24H21N5O3
Molecular Weight
427.46
References & Citations
[1]Borgegard T, et al. First and second generation γ-secretase modulators (GSMs) modulate amyloid-β (Aβ) peptide production through different mechanisms. J Biol Chem. 2012 Apr 6;287 (15) :11810-9.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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CatalogName
GTR19274361-01AZ1136

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