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5-Hydroxy Propafenone (hydrochloride)

CAT: 0804-HY-12773A-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-12773A-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
5-Hydroxy Propafenone (hydrochloride) is an inhibitor of cardiac myocyte repolarizing currents. 5-Hydroxy Propafenone is an active metabolite of propafenone. 5-Hydroxy Propafenone (hydrochloride) inhibits transient outward potassium current (Ito) in isolated human arterial myocytes with an IC50 of 1.5 μM. 5-Hydroxy Propafenone (hydrochloride) is potent Ito inhibitor in neonatal rat ventricular myocytes[1].
CAS Number
86383-32-6
Product Name Alternative
GPV-129 (hydrochloride)
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Biochemical Assay Reagents; Others; Potassium Channel
Related Pathways
Membrane Transporter/Ion Channel; Others
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Smiles
[H]Cl.O=C(C1=CC(O)=CC=C1OCC(O)CNCCC)CCC2=CC=CC=C2
Molecular Formula
C21H28ClNO4
Molecular Weight
393.90
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Cahill, S. A., et al., (2001) . Transient outward current inhibition by propafenone and 5-hydroxypropafenone in cultured neonatal rat ventricular myocytes. Journal of cardiovascular pharmacology, 38 (3), 460–467.
Shipping Conditions
Room temperature
Scientific Category
Reference compound2
Clinical Information
No Development Reported

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