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Tetromycin B

CAT: 0804-HY-126489Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-126489Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Tetromycin B is a cysteine protease inhibitor with Ki values of 0.62, 1.42, 32.5, and 1.59 μM for rhodesain, falcipain-2, cathepsin L, and cathepsin B, respectively. It inhibits the growth of T. brucei in vitro (IC50=30.87 μM) . Tetromycin B is also cytotoxic to HEK293T kidney cells and J774.1 macrophages (IC50s=71.77 and 20.2 μM, respectively) .
CAS Number
180027-84-3
UNSPSC
12352005
Target
Parasite
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Smiles
CC1=C[C@]2([C@@]([H])([C@H](CC[C@@H]2O)C)[C@@](C)([C@@]1(/C(C)=C/CC/C(C)=C/[C@]3([C@]4(C[C@H](C(C)=C3)C)OC5=O)C)[H])C(C5=C4O)=O)[H]
Molecular Formula
C34H46O5
Molecular Weight
534.73
References & Citations
[1]Pimentel-Elardo, et al. New tetromycin derivatives with anti-trypanosomal and protease inhibitory activities. Mar. Drugs 9 (10), 1682-1697 (2011) .
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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