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DS42450411

CAT: 0804-HY-125288Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-125288Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DS42450411 is an orally active hepcidin production inhibitor with an IC50 of 32 nM. DS42450411 in an acute inflammatory mouse model induced by IL-6, DS42450411 significantly reduces serum hepcidin levels. DS42450411 can be used for studying iron homeostasis[1].
CAS Number
2247168-13-2
UNSPSC
12352005
Target
Ferroportin
Related Pathways
Membrane Transporter/Ion Channel
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Smiles
NC1=C2C(C)(C)CC3=CC(C([C@H]4CC[C@H](N)CC4)=C)=CC=C3C2=NC=N1
Molecular Formula
C22H28N4
Molecular Weight
348.48
References & Citations
[1]Fukuda T, et al. Discovery of DS42450411 as a potent orally active hepcidin production inhibitor: Design and optimization of novel 4-aminopyrimidine derivatives. Bioorg Med Chem Lett. 2018 Nov 1;28 (20) :3333-3337.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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