Agelastatin A

CAT: 0804-HY-125132Size: 1 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-125132Size:1 mg

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Description

Agelastatin A ((-) -Agelastatin A; AglA), a tetracyclic alkaloid isolated from the sponge Agelas dendromorpha, induces apoptosis and arrests cells in the G2/M phase of the cell cycle, exhibiting antitumor activity[1].

CAS Number

152406-28-5

Product Name Alternative

(-) -Agelastatin A; AglA

UNSPSC

12352005

Target

Apoptosis

Related Pathways

Apoptosis

Field of Research

Cancer

Solubility

10 mM in DMSO

Smiles

BrC(N1[C@@]2([H])[C@](N3)([H])[C@@]4([H])[C@@](C2)(N(C(N4)=O)C)O)=CC=C1C3=O

Molecular Formula

C12H13BrN4O3

Molecular Weight

341.16

References & Citations

[1]Sunkyu Han, et al. Synthesis and anticancer activity of all known (-) -agelastatin alkaloids. J Org Chem. 2013 Dec 6;78 (23) :11970-84. |[2]E Paige Stout, et al. Potent fluorinated agelastatin analogues for chronic lymphocytic leukemia: design, synthesis, and pharmacokinetic studies. J Med Chem. 2014 Jun 26;57 (12) :5085-93. doi: 10.1021/jm4016922. Epub 2014 Jun.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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