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VU6010608

CAT: 0804-HY-124985Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-124985Size:1 Each
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Description
VU6010608 is a blood-brain barrier-crossing mGlu7 negative allosteric modulator (IC50 = 0.76 μM) . VU6010608 can block long-term enhancement (LTP) of SC-CA1 synapses in mouse brain slices induced by high-frequency stimulation. VU6010608 can be used for research on neurological diseases[1].
CAS Number
2165325-42-6
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
MGluR
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Neurological Disease
Smiles
O=C(NC1=CC(OC(F)(F)F)=CC=C1N2N=CN=C2)C3=CC=C(OC)C(OC)=C3
Molecular Formula
C18H15F3N4O4
Molecular Weight
408.33
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
References & Citations
[1]Reed CW, et al.VU6010608, a Novel mGlu7 NAM from a Series of N- (2- (1H-1,2,4-Triazol-1-yl) -5- (trifluoromethoxy) phenyl) benzamides. ACS Med Chem Lett. 2017 Nov 8;8 (12) :1326-1330.
Shipping Conditions
Room temperature
Scientific Category
Reference compound2
Clinical Information
No Development Reported

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CatalogName
GTR19222683-01VU6010608

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