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ZPL-5212372

CAT: 0804-HY-124852Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-124852Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ZPL-5212372 (PF 5212372) is a cPLA2α inhibitor (IC50 = 7 nM) . ZPL-5212372 inhibits the release of prostaglandin D2 (PGD2), cysteyl leukotrienes, leukotriene B4, thromboxane A2, and PGD2 from human lung cells. ZPL-5212372 inhibits delayed bronchoconstriction and airway hyperresponsiveness in a sheep allergic inflammation model. ZPL-5212372 may be used in asthma research[1].
CAS Number
916136-25-9
Product Name Alternative
PF 5212372
UNSPSC
12352005
Target
Leukotriene Receptor; Phospholipase; Prostaglandin Receptor
Related Pathways
GPCR/G Protein; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Smiles
O=C(O)CCC1=CC=C(S(=O)(CCC2=C(CCNS(=O)(CC3=CC=CC=C3C(F)(F)F)=O)N(C(C4=CC=CC=C4)C5=CC=CC=C5)C6=C2C=C(Cl)C=C6)=O)C=C1
Molecular Formula
C42H38ClF3N2O6S2
Molecular Weight
823.34
References & Citations
[1]Hewson CA, et al. Preclinical evaluation of an inhibitor of cytosolic phospholipase A2α for the treatment of asthma. J Pharmacol Exp Ther. 2012 Mar;340 (3) :656-65.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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