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S1PL-IN- 2

CAT: 0804-HY-124655Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-124655Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
S1PL-IN-2 (Compound 28) is a potent sphingosine-1-phosphate lyase (S1PL) inhibitor with an IC50 of 120 nM. S1PL-IN-2 shows an IC50 of 230 nM on HEK293 cells. S1PL-IN-2 block the conversion of Vitamin B6 into the active pyridoxal-4-phosphate cofactor required for S1P lyase activity. S1PL-IN-2 can be used for the researches of inflammation and immunology, such as rheumatoid arthritis[1].
CAS Number
1897406-94-8
UNSPSC
12352005
Target
LPL Receptor
Related Pathways
GPCR/G Protein
Field of Research
Inflammation/Immunology
Smiles
O=C(C1=NOC(C)=C1)NC(C2=CC=CC=C2)CNCC3=CC(C)=C(OCCCC)C=C3C
Molecular Formula
C26H33N3O3
Molecular Weight
435.56
References & Citations
[1]Dinges J, et al. Hit-to-lead evaluation of a novel class of sphingosine 1-phosphate lyase inhibitors. Bioorg Med Chem Lett. 2016 May 1;26 (9) :2297-302.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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T83910-01S1PL-IN-31
365037SGPL1 (Sphingosine 1 Phosphate Lyase 1, SPL, S1PL, Sphingosine-1-phosphate aldolase)
133270-HRPSGPL1 (Sphingosine-1-phosphate Lyase 1, SP-lyase 1, S1PL, SPL 1, SPL, hSPL, KIAA1252, Sphingosine-1-phosphate Aldolase) (HRP)
133270SGPL1 (Sphingosine-1-phosphate Lyase 1, SP-lyase 1, S1PL, SPL 1, SPL, hSPL, KIAA1252, Sphingosine-1-phosphate Aldolase)
133270-ML650SGPL1 (Sphingosine-1-phosphate Lyase 1, SP-lyase 1, S1PL, SPL 1, SPL, hSPL, KIAA1252, Sphingosine-1-phosphate Aldolase) (MaxLight 650)
133270-FITCSGPL1 (Sphingosine-1-phosphate Lyase 1, SP-lyase 1, S1PL, SPL 1, SPL, hSPL, KIAA1252, Sphingosine-1-phosphate Aldolase) (FITC)
133270-PESGPL1 (Sphingosine-1-phosphate Lyase 1, SP-lyase 1, S1PL, SPL 1, SPL, hSPL, KIAA1252, Sphingosine-1-phosphate Aldolase) (PE)
133270-ML750SGPL1 (Sphingosine-1-phosphate Lyase 1, SP-lyase 1, S1PL, SPL 1, SPL, hSPL, KIAA1252, Sphingosine-1-phosphate Aldolase) (MaxLight 750) discontinued
133270-APCSGPL1 (Sphingosine-1-phosphate Lyase 1, SP-lyase 1, S1PL, SPL 1, SPL, hSPL, KIAA1252, Sphingosine-1-phosphate Aldolase) (APC)
133270-BiotinSGPL1 (Sphingosine-1-phosphate Lyase 1, SP-lyase 1, S1PL, SPL 1, SPL, hSPL, KIAA1252, Sphingosine-1-phosphate Aldolase) (Biotin)

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