Lunularin

CAT: 0804-HY-124529-01Size: 100 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-124529-01Size:100 mg

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Description

Lunularin (Compound 3), a monoterpene, is a metabolite of gut microbiota-derived Resveratrol. Lunularin can be isolated from the liverwort Conocephalum conicum. Lunularin is a selective 11β-HSD1 inhibitor with IC50s of 45.44 and 17.39 μM for human 11β-HSD1 and rat 11β-HSD1, respectively. Lunularin has significant anti-inflammatory and anti-cancer activities[1][2][3].

CAS Number

37116-80-6

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

11β-HSD; Endogenous Metabolite

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Purity

99.87

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

OC1=CC=C(CCC2=CC=CC(O)=C2)C=C1

Molecular Formula

C14H14O2

Molecular Weight

214.26

Precautions

H302, H315, H319, H335

References & Citations

[1]Suire C, et al. Chirality of terpenoids isolated from the liverwort Conocephalum Conicum[J]. Phytochemistry, 1982, 21 (2) : 349-352.|[2]Li F, et al. Gut Microbiota-Derived Resveratrol Metabolites, Dihydroresveratrol and Lunularin, Significantly Contribute to the Biological Activities of Resveratrol. Front Nutr. 2022 May 11;9:912591.|[3]Hu C, et al. Resveratrol analogues and metabolites selectively inhibit human and rat 11β-hydroxysteroid dehydrogenase 1 as the therapeutic drugs: structure-activity relationship and molecular dynamics analysis. SAR QSAR Environ Res. 2024 Jul;35 (7) :641-663.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, stored under nitrogen)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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