W2476

CAT: 0804-HY-124483Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-124483Size:1 Each

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

W2476 is a regulator of thioredocin-interacting protein signaling pathway. W2476 promotes competitive binding of forkhead box O1 transcription factor (FOXO1) . W2476 can ameliorate β-cell dysfunction and enhance insulin secretion in diabetic mouse model[1][2].

CAS Number

432016-77-8

UNSPSC

12352005

Target

Others

Related Pathways

Others

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Smiles

O=C(C)C1=CC=C(C=C1)OCCN2C=NC3=C2N=CN=C3N

Molecular Formula

C15H15N5O2

Molecular Weight

297.31

References & Citations

[1]Li, T., et al., (2017) . W2476 ameliorates β-cell dysfunction and exerts therapeutic effects in mouse models of diabetes via modulation of the thioredoxin-interacting protein signaling pathway. Acta pharmacologica Sinica, 38 (7), 1024-1037.|[2]Zhong, L., et al., (2021) . W2476 represses TXNIP transcription via dephosphorylation of FOXO1 at Ser319. Chemical biology & drug design, 97 (5), 1089-1099.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

W2476

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