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Eicosatetraynoic acid

CAT: 0804-HY-124108Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-124108Size:1 mg
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Description
Eicosatetraynoic acid (ETYA) is a nonspecific inhibitor of cyclooxygenase and lipoxygenase (ID50=8 μM and 4 μM, respectively) [1]. Eicosatetraynoic acid (ETYA) activates PPARα and PPARγ chimeras at 10 μM[2]. Eicosatetraynoic acid specifically interferes with the replication of the cowpox virus both in vivo and in vitro[3]. Eicosatetraynoic acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
CAS Number
1191-85-1
Product Name Alternative
ETYA
UNSPSC
12352211
Target
COX; Orthopoxvirus; PPAR
Related Pathways
Anti-infection; Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Field of Research
Others
Purity
99.9
Solubility
DMSO : 2 mg/mL (ultrasonic) |Ethanol : < 1 mg/mL
Smiles
CCCCCC#CCC#CCC#CCC#CCCCC(O)=O
Molecular Formula
C20H24O2
Molecular Weight
296.40
References & Citations
[1]Hammarström S, et al. Selective inhibition of platelet n-8 lipoxygenase by 5,8,11-eicosatriynoic acid. Biochim Biophys Acta. 1977 Jun 22;487 (3) :517-9.|[2]Kliewer SA, et al. A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor gamma and promotes adipocyte differentiation. Cell. 1995 Dec 1;83 (5) :813-9.|[3]Palumbo GJ, et, al. Inhibitors of the lipoxygenase pathway specifically block orthopoxvirus replication. Virology. 1991 Jan;180 (1) :457-63.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
COX

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